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SUMMARY:Observation of universal dynamics in the recovery of single cells 
 to stress - Prof. Nathalie Balaban (The Hebrew University of Jerusalem)
DTSTART:20210511T130000Z
DTEND:20210511T140000Z
UID:TALK160453@talks.cam.ac.uk
CONTACT:Margarida Rodrigues
DESCRIPTION:Stress response in cells is understood as an organized adaptiv
 e response that allows cells to respond to changes in external conditions 
 by activating specific pathways. Here we investigate the dynamics of singl
 e cells when perturbed by acute stress beyond their adaptive potential. We
  show that when the growth of bacteria is arrested by an acute transient s
 tress\, their relaxation dynamics back to growth after the stress follow a
  universal behavior. By introducing a generic model for the cellular netwo
 rk\, we show that the universal relaxation dynamics can predict the outcom
 e of antibiotic persistence measurements.  Further experiments under diffe
 rent stress conditions support the predictions of the model and identify a
  typical time-scale for the universal relaxation dynamics. Our results may
  account for the ubiquitous antibiotic persistence phenotype\, as well as 
 for the difficulty in attempts to link it to specific genes. More generall
 y\, our approach suggests that cellular response to acute perturbations ma
 y be described by universal properties of large random networks rather tha
 n by specific pathway activation.\n\nRegistration needed (click link)\nhtt
 ps://us02web.zoom.us/webinar/register/WN_UrwqwHCyTcWNmFWNb4fjEg\n\nMore in
 fo at www.physbiol.cam.ac.uk
LOCATION:Zoom (copy url or see details below) bit.ly/2PMNjMS
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