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SUMMARY:How filopodia locally protrude from cell plasma membrane - Patrici
 a Bassereau (Institut Curie\, Paris)
DTSTART:20210615T130000Z
DTEND:20210615T140000Z
UID:TALK160462@talks.cam.ac.uk
CONTACT:Margarida Rodrigues
DESCRIPTION:Cell membranes are highly deformable and can be strongly curve
 d. For instance\, cells extend thin and dynamic tubular plasma membrane pr
 otrusions for sensing their surroundings and for their motion called "filo
 podia". These finger-like protrusions are formed by actin parallel filamen
 ts pushing against the membrane while they polymerize. How actin is locall
 y recruited to exert this pushing force has been debated for a long time. 
 With in vitro reconstitution and mechanical experiments on liposomes\, we 
 have shown that the unique capability of the curved I-BAR protein IRSp53 t
 o couple with membrane curvature induces its clustering on membranes\, thu
 s the local recruitment of actin polymerases and eventually actin growth. 
 However\, a pivotal IRSp53 activation step is necessary in vivo to precise
 ly regulate the time and localization of filopodia growth.\n\nRegistration
  needed (click link) https://us02web.zoom.us/webinar/register/WN_WL_pncgHQ
 q64Pwykyb2Ddg\n\nMore info at www.physbiol.cam.ac.uk
LOCATION:Zoom (copy url or see details below) https://us02web.zoom.us/webi
 nar/register/WN_WL_pncgHQq64Pwykyb2Ddg
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