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SUMMARY:Phase separation as an organizing principle in biology and disease
  - Simon Alberti\, Technische Universität Dresden
DTSTART:20210609T093000Z
DTEND:20210609T103000Z
UID:TALK160495@talks.cam.ac.uk
CONTACT:Anne Jacobs
DESCRIPTION:Condensates formed by liquid-liquid phase separation can creat
 e functionally distinct membraneless compartments consisting of proteins a
 nd RNAs\, which have major roles in cellular organization and physiology. 
 RNP granules are a specific type of condensates that assemble by phase sep
 aration of RNA-binding proteins (RBPs) and RNA. Recent data also suggest t
 hat aberrant phase transitions of RBPs into RNA/protein aggregates may be 
 closely tied or even causative to the pathogenesis associated with disease
 s such as amyotrophic lateral sclerosis. \nIn this talk\, I will discuss h
 ow the concept of biomolecular condensates has expanded our view of biolog
 y and disease. I will introduce in vitro reconstitution systems based on c
 ondensation that now allow us to rebuild complex structures such as RNP gr
 anules in the test tube. Using these reconstitution systems\, we have gain
 ed important insights into the molecular rules of RNP condensates\, such a
 s the molecular grammar and conformational changes underlying condensate a
 ssembly\, the driving forces and amino acids that govern aberrant phase tr
 ansitions\, and molecular mechanisms of condensate regulation and control.
  I will further discuss how the concept of phase separation has allowed us
  to identify novel functions of RNP condensates\, and I will demonstrate h
 ow phase separation can be used by cells to sense and respond to changes i
 n the environment and regulate fundamental cellular processes such as prot
 ein synthesis.\n
LOCATION:https://zoom.us/j/98205706861?pwd=MitmZ2pqVHNKWmdwMWlVUkpWZkNDdz0
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