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SUMMARY:Bedside to bench and back again\, a path to translational pain res
 earch? - Dr Ewan St John Smith\, Department of Pharmacology
DTSTART:20210518T150000Z
DTEND:20210518T160000Z
UID:TALK160597@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:*Theme: Beyond the Neuron: glia\, vascular and immune cells*\n
 \n*Abstract:* Pain has both a sensory and emotional component and is drive
 n by activation of sensory neurones called nociceptors that are tuned to d
 etect noxious stimuli in a process called nociception. Although nociceptio
 n functions as a detect and protect mechanism. and is found in many organi
 sms\, this system becomes dysregulated in a number of conditions where chr
 onic pain presents as a key symptom\, for example osteoarthritis. Nocicept
 ors do not innervate empty space though and do not act alone. Going beyond
  the neurone\, other cell types\, such as fibroblast-like synoviocytes int
 eract with and modify the function of nociceptors\, which is likely a key 
 contributor to the chronification of pain. In this talk\, I will look at h
 ow combining pre-clinical mouse work with human tissue and genetics might 
 provide a way to accelerate new analgesics from bench to bedside\, giving 
 examples from our work in joint pain\, bowel pain and labour pain.\n\n*Bio
 graphy:* Ewan completed his undergraduate degree in pharmacology at the Un
 iversity of Bath\, followed by a PhD at the University of Cambridge workin
 g on acid-sensing ion channels. He then moved to work at the Max-Delbrück
  Centre in Berlin as an Alexander von Humboldt Research Fellow\, where he 
 began working on pain peculiarities of the naked mole-rat. This was follow
 ed by a 1-year stint at the Skirball Institute of Biomolecular Medicine at
  NYU as a Max Kade Foundation Fellow\, where he worked on CO2-sensing in C
 . elegans. In 2013 he was appointed to a Lectureship in Pharmacology at th
 e University of Cambridge where his research group focuses on understandin
 g the molecular basis of nociception using mice\, naked mole-rats and huma
 n tissue\, as well as investigating the cancer resistance and healthy agei
 ng of naked mole-rats. He was promoted to Senior Lecturer in 2017 and Read
 er in 2019\, also being a Fellow of Corpus Christi College and Deputy Head
  of Department in Pharmacology since 2020. Work in the Smith lab is curren
 tly funded by the BBSRC\, MRC\, Versus Arthritis\, Dunhill Medical Trust\,
  Astra Zeneca\, Beiersdorf and GSK.\n\n*Selected papers*\n# Lee\, M.\, Nah
 orski\, M.\, Hockley\, J.R.F.\, Lu\, V.\, Ison\, G.\, Pattison\, L.A.\, Ca
 llejo\, G.\, Stouffer\, K.\, Fletcher\, E.\, Drissi\, I.\, Wheeler\, D.\, 
 Ernfors\, P.\, Menon\, D.\, Reimann\, F.\, Smith\, E.S. and Woods\, C.G. (
 2020). Human labour pain is influenced by the voltage-gated potassium chan
 nel KV6.4 subunit. Cell Reports\, 32\, 107941\n# Chakrabarti\, S.\, Pattis
 on\, L.A.\, Doleschall\, B.\, Rickman\, R.H.\, Callejo\, G.\, Heppenstall\
 , P.A. and Smith\, E.S. (2020). Intra-articular AAV-PHP.S mediated chemoge
 netic targeting of knee-innervating DRG neurons alleviates inflammatory pa
 in in mice. Arth Rheum\, 72\, 1749-1758. \n# Chakrabarti\, S.\, Hore\, Z.\
 , Pattison\, L.A.\, Lalnunhlimi\, S.\, Bhebhe\, C.N.\, Callejo\, G.\, Bulm
 er\, D.C.\, Taams\, L.S.\, Denk\, F. and Smith\, E.S. (2020). Sensitizatio
 n of knee-innervating sensory neurons by tumor necrosis factor-α activate
 d fibroblast-like synoviocytes: an in vitro\, co-culture model of inflamma
 tory pain. Pain\, 161\, 2129-2141.\n# Chakrabarti\, S.\, Jadon\, D.R.\, Bu
 lmer D.C. and Smith\, E.S. (2020) Human osteoarthritic synovial fluid incr
 eases excitability of mouse dorsal root ganglion sensory neurons: an in-vi
 tro translational model to study arthritic pain. Rheumatology\, 59\, 662-6
 67\n# Hockley\, J.R.F.\, Taylor\, T.S.\, Callejo\, G.\, Wilbrey\, A.L.\, G
 utterridge\, A.\, Bach\, K.\, Winchester\, W.J.\, Bulmer\, D.C.\, McMurray
 \, G. and Smith\, E.S. (2019) Single-cell RNAseq reveals seven classes of 
 colonic sensory neuron. Gut\,68\, 633-644.\n\nRegister in advance for this
  meeting: https://us02web.zoom.us/meeting/register/tZcodeCrpz0oHtbezXOTXme
 nIqeR0dcYnbpJ\n\nAfter registering\, you will receive a confirmation email
  containing information about joining the meeting.\n
LOCATION:Register on Zoom - link in abstract
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