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SUMMARY:Deciphering the Genomic Rosetta Stone   - Prof. Rob Phillips (Calt
 ech)  
DTSTART:20210616T160000Z
DTEND:20210616T170000Z
UID:TALK160657@talks.cam.ac.uk
CONTACT:Dr. Adrien Hallou
DESCRIPTION:The ability to read the DNA sequences of different organisms h
 as transformed biology in much the same way that the telescope transformed
  astronomy. And yet\, much of the sequence found in these genomes is as en
 igmatic as the Rosetta Stone was to early Egyptologists. With the aim of m
 aking steps to crack the genomic Rosetta Stone\, I will describe unexpecte
 d ways of using the physics of information transfer first developed at Bel
 l Labs for thinking  about telephone communications to try to decipher the
  meaning of the regulatory features of genomes. Specifically\, I will show
  how we have been able to explore genes for which we know nothing about ho
 w they are regulated by using a combination of mutagenesis\, deep sequenci
 ng and the physics of information\, with the result that we now have falsi
 fiable hypotheses about how those genes work. With those results in hand\,
  I will show how simple tools from statistical physics can be used to pred
 ict the level of expression of different genes\, followed by a description
  of precision measurements used to test those predictions. Bringing the tw
 o threads of the talk together\, I will think about next steps in reading 
 and writing genomes at will.
LOCATION:Webinar
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