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SUMMARY:LMB Seminar: Systemic regulation of brain aging and function - Ton
 y Wyss-Coray\, D. H. Chen Professor II\, Stanford University\, USA
DTSTART:20210525T150000Z
DTEND:20210525T160000Z
UID:TALK160669@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Brain aging leads to cognitive decline and is the main risk fa
 ctor for sporadic forms of neurodegenerative diseases including Alzheimer
 ’s disease. While brain cell- and tissue-intrinsic factors are likely ke
 y determinants of the aging process recent studies document a remarkable s
 usceptibility of the brain to circulatory factors. Thus\, blood borne fact
 ors from young mice or humans are sufficient to slow aspects of brain agin
 g and improve cognitive function in old mice and\, vice versa\, factors fr
 om old mice are detrimental for young mice and impair cognition. In trying
  to understand the molecular basis of these observations we found evidence
  that the cerebrovasculature is an important target and that brain endothe
 lial cells show prominent age-related transcriptional changes in response 
 to plasma. We discovered that plasma proteins are taken up broadly into br
 ain endothelial cells and that this process various greatly between indivi
 dual cells and with aging. We are exploring the relevance of these finding
 s for neurodegeneration and potential application towards therapies.
LOCATION:Webinar -  Zoom link: https://zoom.us/j/91691820397?pwd=aUNFUFFib
 1V5S2V4RUswRmlhN0pRQT09
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