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SUMMARY:Probing proteome foldedness and conformational changes under prote
 ostasis stresses - Prof. Danny Hatters\, University of Melbourne
DTSTART:20210526T080000Z
DTEND:20210526T090000Z
UID:TALK160690@talks.cam.ac.uk
CONTACT:Kimberley Callaghan
DESCRIPTION:The Hatters lab studies impacts of protein misfolding and aggr
 egation in cultured cell models of neurodegenerative diseases.  We have de
 veloped approaches to examine the changes in solubility of the proteome in
  context of Huntington’s disease cell models and when we perturb specifi
 c elements of the quality control systems that regulate proteostasis.  We 
 have also developed approaches with chemical reagents to monitor cysteine 
 reactivity to probe changes in proteome foldedness and conformation.  I wi
 ll discuss recent findings from our laboratory including unpublished work 
 that provide insight to the mechanisms of how proteins in cells change the
 ir structure and function in response to stresses and stimuli.
LOCATION:https://zoom.us/j/92985851709
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