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SUMMARY:Psychological mechanisms and functions of 5-HT and SSRIs in potent
 ial therapeutic change: Lessons from the serotonergic modulation of action
  selection\, learning\, affect\, and social cognition - Clark Roberts\, De
 partment of Psychology
DTSTART:20210526T150000Z
DTEND:20210526T160000Z
UID:TALK160774@talks.cam.ac.uk
CONTACT:Katharina Zuhlsdorff
DESCRIPTION:Uncertainty regarding which psychological mechanisms are funda
 mental in mediating SSRI treatment outcomes and wide-ranging variability i
 n their efficacy has raised more questions than it has solved. Since subje
 ctive mood states are an abstract scientific construct\, only available th
 rough self-report in humans\, and likely involving input from multiple top
 -down and bottom-up signals\, it has been difficult to model at what level
  SSRIs interact with this process. Converging translational evidence indic
 ates a role for serotonin in modulating context-dependent parameters of ac
 tion selection\, affect\, and social cognition\; and concurrently supporti
 ng learning mechanisms\, which promote adaptability and behavioural flexib
 ility. We examine the theoretical basis\, ecological validity\, and intera
 ction of these constructs and how they may or may not exert a clinical ben
 efit. Specifically\, we bridge crucial gaps between disparate lines of res
 earch\, particularly findings from animal models and human clinical trials
 \, which often seem to present irreconcilable differences. In determining 
 how SSRIs exert their effects\, our approach examines the endogenous funct
 ions of 5-HT neurons\, how 5-HT manipulations affect behaviour in differen
 t contexts\, and how their therapeutic effects may be exerted in humans 
 – which may illuminate issues of translational models\, hierarchical mec
 hanisms\, idiographic variables\, and social cognition.
LOCATION:Zoom
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