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SUMMARY:Building organs – emergence of form and fate through local force
  imbalance - Rashmi Priya\, The Francis Crick Institute\, London
DTSTART:20210614T133000Z
DTEND:20210614T143000Z
UID:TALK160996@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:How diverse cell fates and complex forms emerge and interact a
 cross scales during\norganogenesis remains unknown. A critical step during
  vertebrate heart development is trabeculation\, during which the primitiv
 e heart transforms from a simple epithelium to an intricate topological st
 ructure consisting of two distinct cell types – outer compact and inner 
 trabecular layer cardiomyocytes (CMs). Trabeculation defects cause cardiom
 yopathies and embryonic lethality\, yet how tissue symmetry is broken to s
 pecify trabecular CMs is unknown. We now report that local tension heterog
 eneity drives organ-scale patterning and cell fate decisions during zebraf
 ish cardiac trabeculation. Tissue-scale crowding induces local differences
  in CM contractility\, which subsequently triggers stochastic delamination
  of CMs from the outer compact layer to seed the inner trabecular layer. C
 Ms with higher contractility delaminate\, even in the absence of critical 
 biochemical regulators (Nrg/Erbb2) to seed the trabecular layer. Notably\,
  mechanics direct CM fate specification\, as mechanical segregation of CMs
  into compact versus trabecular layer is sufficient to induce differential
  Notch activity and apicobasal polarity. Notch in turn suppresses CM actom
 yosin machinery to limit excessive delamination\, thereby preserving the m
 yocardial wall architecture. Thus\, multiscale synergistic interactions be
 tween mechanical forces and cell fate ensures robust self-organized organ 
 patterning.\n
LOCATION:Online
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