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SUMMARY:&quot\;Investigating the role of Syndecan\, a conserved heparan su
 lphate proteoglycan\, in the maintenance and proliferation of progenitor c
 ells in the adult Drosophila midgut&quot\; - Buffy Eldridge\, PDN\, Univer
 sity of Cambridge
DTSTART:20210607T133000Z
DTEND:20210607T143000Z
UID:TALK160999@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:The stem cell niche is a complex microenvironment which regula
 tes stem cell behaviour through secreted\, cell-cell contact and mechanica
 l cues. An under-studied component of epithelial stem cell niches is the b
 asement membrane\, a thin\, laminar structure to which cells adhere basall
 y via adhesion receptors\, including Integrins\, Dystroglycan and Syndecan
 . Using the adult Drosophila midgut as a model system to investigate the r
 ole of adhesion receptors in directing progenitor cell behaviour in vivo\,
  we identified the laminin receptor Syndecan as a regulator of tissue rene
 wal. Syndecan knockdown causes progenitor cells to detach from the basemen
 t membrane and be lost from the intestinal epithelium. Interestingly\, pro
 genitor depletion does not lead to major tissue attrition over time but to
  retention of old differentiated cells for longer periods. Whilst this pre
 serves tissue integrity in the short term\, it could potentially have dele
 terious effects as old cells accumulate mutations or become damaged by loc
 al insults. To reveal how Syndecan contributes to progenitor maintenance a
 nd communication with neighbouring cells\, our ongoing work investigates w
 hat subset of progenitors depend on Syndecan activity\, and which signalli
 ng pathways become disrupted in its absence.  
LOCATION:Online
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