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SUMMARY:Regulation of Phyllotaxis by Auxin Transport Proteins - Henrik Ahl
 \, Sainsbury's laboratory\, University of Cambridge
DTSTART:20210601T133000Z
DTEND:20210601T143000Z
UID:TALK161005@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:Plants rely on local accumulation of the phytohormone auxin fo
 r a wide range of processes crucial for functional development. In the pla
 nt shoot\, local auxin maxima specify initiation sites for new organs\, su
 ch as flowers. Active transport of auxin by PIN proteins\, which polarise 
 on cell membranes\, is a primary driver for the formation of auxin maxima\
 , but the intricacies of PIN-mediated auxin transport is not fully underst
 ood. To this end\, we have combined computational and experimental approac
 hes to quantitatively assess the cellular abundance and polarity patternin
 g of the auxin efflux carrier PIN1\, as well as the resulting auxin patter
 n following comprehensive simulations of auxin transport as mediated by ac
 tive and passive transport mechanisms. We find that our PIN1 has strong ab
 undance and polarity patterning correlating strongly with the developmenta
 l stage of establishing primordia\, both in the epidermis and provasculatu
 re. Further\, our model suggests that resulting local PIN1 and auxin maxim
 a have shifted profiles relative to the developmental stage of the corresp
 onding primordium\, implicating a time-scale for PIN1-auxin feedback coupl
 ing. In addition\, we analyse the patterning of auxin in meristems with co
 mputationally modified patterning of auxin transport proteins\, and provid
 e patterning-based explanatory mechanisms for experimentally observed phen
 otypes. Lastly\, we correlate the geometric properties of cells with the o
 utput of our analysis and model\, linking the timing of local maxima in th
 e shoot to the development of morphologically relevant cellular features.\
 n
LOCATION:Online
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