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SUMMARY:Personalized Deep Brain Stimulation for Obsessive-Compulsive Disor
 der - Dr Martijn Figee\, Icahn School of Medicine at Mount Sinai
DTSTART:20211007T113000Z
DTEND:20211007T123000Z
UID:TALK161029@talks.cam.ac.uk
CONTACT:87079
DESCRIPTION:*Abstract*\nDeep Brain Stimulation (DBS) research is currently
  experiencing a paradigm shift away from the focal effects of stimulation 
 on the target anatomical structure toward its impact on distributed brain 
 networks. The most commonly used DBS target for obsessive-compulsive disor
 der (OCD)\, the anterior limb of the internal capsule (ALIC)\, impacts dis
 tributed brain networks for reward processing\, error salience and inhibit
 ory control. These networks include ALIC-projections to the orbitofrontal 
 cortex\, dorsal anterior cingulate cortex and ventrolateral and dorsolater
 al prefrontal cortex. The recent development of directional segmented DBS 
 leads may allow for selective stimulation of these cortical projections. H
 ere\, I will discuss ongoing work on developing directional white matter t
 ractography stimulation models in OCD patients with ALIC DBS identifying w
 hich projections may be most therapeutic. Ultimately\, these circuit-respo
 nse maps can be used to guide personalized neuromodulation for OCD and oth
 er cross-diagnostic symptom domains involving these circuits. \n\n*Biograp
 hy*\nDr. Figee is a psychiatrist and associate professor of Psychiatry\, N
 eurosurgery\, Neurology and Neuroscience working at the Nash Family Center
  for Advanced Circuit Therapeutics (C-ACT). He is director of the Mount Si
 nai Interventional Psychiatry Program\, focusing on the psychiatric applic
 ation and study of neuromodulation\, in particular deep brain stimulation 
 (DBS) and transcranial magnetic stimulation (TMS). His research focuses on
  the role of reward and mood circuits in neuropsychiatric disorders\, such
  as obsessive-compulsive disorder (OCD)\, depression and Parkinson’s dis
 ease\, and how these circuits can be modulated with DBS. He pioneered the 
 first application of fMRI in DBS-implanted individuals. Dr. Figee aims to 
 progress DBS and other types of neuromodulation as neuropsychiatric interv
 entions\, by investigating its effects on cross-diagnostic outcomes and as
 sociated neural networks. For more information about Dr Figee\, please vis
 it: https://icahn.mssm.edu/profiles/martijn-figee
LOCATION: Webinar  (via Zoom online)
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