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SUMMARY:Bacterial condensates under stress - Professor Stephanie Weber\, M
 cGill University\, Montreal
DTSTART:20211021T130000Z
DTEND:20211021T140000Z
UID:TALK161098@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Living cells are divided into functional compartments called o
 rganelles. In eukaryotes\, lipid membranes separate organelles from the cy
 toplasm such that each compartment maintains a distinct biochemical compos
 ition that is tailored to its function. In contrast\, prokaryotes typicall
 y lack internal membranes and instead must use other mechanisms to spatial
 ly organize the cell. Using fluorescence imaging and single-molecule track
 ing\, we show that E. coli RNA polymerase (RNAP) organizes into clusters t
 hrough liquid-liquid phase separation (LLPS). RNAP clusters\, or "condensa
 tes"\, increase cell survival during stress\, and appear to regulate ribos
 ome biogenesis in response to nutrient availability. Our results demonstra
 te that bacteria\, like eukaryotic cells\, use LLPS to generate membranele
 ss organelles that spatially organize biochemical processes to optimize ce
 ll fitness in various environments. 
LOCATION:Zoom meeting
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