BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:More the bystanders: Learning how microglia eliminate synapses in 
 the Alzheimer brain - Soyon Hong\, UK Dementia Research Institute at Unive
 rsity College London
DTSTART:20210705T150000Z
DTEND:20210705T160000Z
UID:TALK161242@talks.cam.ac.uk
CONTACT:47293
DESCRIPTION:My lab’s research is aimed at identifying whether\, and if s
 o how\, tissue-resident macrophages of the brain and gut contribute to syn
 aptic homeostasis in health and pathology in neurodegenerative diseases in
 cluding Alzheimer’s disease (AD) and Parkinson’s disease (PD).  One ke
 y question my lab is addressing is whether tissue-resident macrophages inc
 luding microglia exist in diverse functional clusters\, and if so\, which 
 ones contribute to neuronal dysfunction in disease using spatial omic appr
 oaches.   A second major question of my lab is to understand whether micro
 glia target synapses or neuronal elements for engulfment in the diseased b
 rains\, and if so\, which ones.  To this end\, we are manipulating neurona
 l circuit activity and lipid/Trem2 signaling pathways as well as assessing
  the role of astrocytes in microglia-mediated synapse elimination.  These 
 findings will help broaden our understanding of how neuroimmune interactio
 ns may go awry during aging and dementia.
LOCATION:https://zoom.us/j/95371168259?pwd=RWcwVFY4UlRLc21DOG5ZVjRzZTNrdz0
 9
END:VEVENT
END:VCALENDAR