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SUMMARY:How does complexity arise from molecular interaction? - Professor 
 Simone Reber\, IRI Life Sciences\, Humboldt-Universität zu Berlin
DTSTART:20220526T130000Z
DTEND:20220526T140000Z
UID:TALK161248@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:The metaphase spindle is an evident example why the size of in
 tracellular organelles matters: The spindle must be large enough and span 
 sufficient distance to physically separate chromosomes into two opposite h
 alves of the cell. While approaching a near to complete proteomic parts li
 sts of the metaphase spindle\, mechanisms that control their defined size 
 remain poorly understood. Cytoplasmic extracts prepared from eggs of the A
 frican clawed frog Xenopus laevis have proven valuable for studying cellul
 ar processes such as spindle assembly and organization. More recently\, co
 mparison with extracts of the related frog Xenopus tropicalis allowed the 
 identification of spindle scaling factors. We are interested in how the bi
 ochemistry of the basic building block of the spindle\, αβ-tubulin\, con
 tributes to spindle assembly and morphology. We combine in vitro reconstit
 ution assays\, state-of-the art imaging and simulations to show how bioche
 mical adaptation on the molecular scale can create physiological structure
 s in the μm scale that enable faithful chromosome segregation.
LOCATION:Zoom meeting
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