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SUMMARY:Epigenetics and genome dynamics: what can we learn from ciliates? 
 - Dr Sandra Duharcourt\, Institut Jacques Monod\, Universite de Paris
DTSTART:20221020T130000Z
DTEND:20221020T140000Z
UID:TALK161254@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Our work aims to understand the fundamental mechanisms governi
 ng chromosome structure and genetic stability in eukaryotes. We study a re
 markable process of genome editing that occurs during development in the u
 nicellular eukaryote Paramecium. This process involves the massive and rep
 roducible elimination of repeated DNA sequences\, such as transposable ele
 ments. It involves small (s)RNA-directed heterochromatin formation and sub
 sequent DNA excision and repair. sRNAs are produced from the germline geno
 me during meiosis and guide the deposition of histone H3 post-translationa
 l epigenetic modifications onto sequences to be eliminated in the developi
 ng somatic nucleus\, and specifically tether the DNA cleavage and repair m
 achinery. We demonstrated that the Paramecium histone methyltransferase Ez
 l1\, a homolog of the mammalian PRC2 catalytic subunit\, catalyzes H3K27me
 3 and H3K9me3 on TEs. We currently investigate how the Ezl1-associated com
 plex is recruited to TEs\, and how the histone H3 post-translational modif
 ications trigger DNA cleavage and repair. 
LOCATION:Zoom meeting
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