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SUMMARY:Asymmetric cell division and germline immortality - Professor Yuki
 ko Yamashita\, Whitehead Institute for Biomedical Research\, Cambridge\, M
 A
DTSTART:20220224T140000Z
DTEND:20220224T150000Z
UID:TALK161257@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Germline is the only lineage that is capable of passing geneti
 c information to the next generation. It remains poorly understood how the
  genome of the germ cells can be passed from generation to the next throug
 h evolutionary time scale. ribosomal DNA (rDNA)\, which encodes catalytic 
 subunits of ribosome\, exists as 100s of tandem repeats to meet the demand
  of ribosome biogenesis. This repetitiveness causes copy number loss durin
 g aging. Here I describe the mechanism by which rDNA copy number is mainta
 ined in germline to confer 'immortality'.
LOCATION:Zoom meeting
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