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SUMMARY:Exploring host-tumour metabolic interactions using Drosophila - Dr
  Susumu Hirabayashi\, MRC London Institute of Medical Sciences\, Imperial 
 College London
DTSTART:20220303T140000Z
DTEND:20220303T150000Z
UID:TALK161260@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Cancer is increasingly viewed as a systemic disease associated
  with a range of host metabolic changes including obesity\, insulin resist
 ance\, and cachexia/muscle wasting syndrome\, each of which alters the hos
 t metabolic and nutritional environment. Cancer cells actively acquire nut
 rients from the extracellular space to support their growth\, but how canc
 er cells sense and respond to changes in systemic nutrient availability re
 mains incompletely understood. We leverage the fruit fly Drosophila melano
 gaster as a model system to explore host-tumour metabolic and nutritional 
 interactions. In this seminar\, I present how our Drosophila studies have 
 started reveal mechanisms by which tumours sense and exploit extracellular
  nutrients in the context of both obesity and systemic muscle wasting. I a
 lso demonstrate how tumours with different genetic alterations respond dif
 ferently to obesity.
LOCATION:Zoom meeting
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