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SUMMARY:Mechanics of blastocyst morphogenesis - Dr Jean-Léon Maître\, In
 stitut Curie\, Paris
DTSTART:20220310T140000Z
DTEND:20220310T150000Z
UID:TALK161263@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:During pre-implantation development\, the mammalian embryo for
 ms the blastocyst. The architecture of the blastocyst is essential to the 
 specification of the first mammalian lineages and to the implantation of t
 he embryo. Consisting of an epithelium enveloping a fluid-filled lumen and
  the inner cell mass\, the blastocyst is sculpted by a succession of morph
 ogenetic events. These deformations result from the changes in the forces 
 and mechanical properties of the tissue composing the embryo. Combining mi
 croscopy\, image analysis\, biophysical tools and genetics\, we study the 
 mechanical and cellular changes leading to the formation of the blastocyst
 . In particular\, we uncover the distinct mechanical strategies adopted by
  human and mouse embryos to become compacted and how spindle instabilities
  can trigger cell fragmentation.
LOCATION:Zoom meeting
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