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SUMMARY:Regulation of physiology via a dietary lipid metabolite. - Profess
 or Aurelio Teleman\, German Cancer Research Center (DKFZ)\, Heidelberg
DTSTART:20220616T130000Z
DTEND:20220616T140000Z
UID:TALK161314@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Metabolism and cell signaling are tightly interconnected\, wit
 h each one regulating the other. The mechanisms how cell signaling regulat
 es metabolic pathways have been extensively studied\, for instance via tra
 nscriptional regulation of gene expression or via post-translational regul
 ation of metabolic enzymes. I will discuss the other direction - how metab
 olites regulate signaling pathways. One mechanism is via formation of post
 -translational modifications of protein via metabolites. One example of su
 ch a reversible modification is S-acylation\, the attachment of lipids to 
 protein cysteines via thioester bonds. I will discuss recent evidence that
  different lipids compete for acylation of single sites on proteins\, ther
 eby regulating their function.
LOCATION:Zoom meeting
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