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SUMMARY:A guiding torch at the poles: key roles of the centrosome during a
 symmetric cell division - Dr Fernando Monje Casas\, Andalusian Center for 
 Molecular Biology and Regenerative Medicine (CABIMER)\, Seville
DTSTART:20220512T130000Z
DTEND:20220512T140000Z
UID:TALK161320@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:The distribution of the duplicated genome during cell division
  is facilitated by the spindle\, a remarkable and complex cellular machine
 ry formed by a bipolar array of microtubules that guide the segregation of
  chromosomes. The microtubules from the spindle nucleate from microtubule-
 organizing centers (MTOCs)\, specialized structures that localize at both 
 spindle poles and that are known as centrosomes in higher eukaryotes or sp
 indle pole bodies (SPBs) in yeast cells. Besides their function in chromos
 ome segregation\, spindle MTOCs constitute critical platforms where multip
 le signaling pathways converge to regulate essential processes in the cell
 \, such as the proper and timely regulation of mitosis\, the coordination 
 of cell cycle progression and cell metabolism or the functionality of the 
 mitotic checkpoints. Centrosomes and SPBs play a particularly relevant rol
 e in cells that display an asymmetric division\, since these structures ca
 n be used to facilitate the unequal distribution of molecules and organell
 es between the mother and daughter cells\, thus contributing to the genera
 tion of two cells with a differential fate or proliferative capacity. Inte
 restingly\, spindle MTOCs themselves can be non-randomly inherited during 
 asymmetric cell divisions\, an evolutionary process that we have recently 
 demonstrated to be important for the maintenance of a full replicative lif
 espan in budding yeast. I will present recent research from our group that
  sheds new light on the role of MTOCs as epicenters for the integration an
 d coordination of key cellular processes during asymmetric cell division\,
  as well as on their importance during the aging process and in the determ
 ination of a differential cellular fate.
LOCATION:Zoom meeting
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