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SUMMARY:Genetic correlates of phenotypic heterogeneity in autism - Varun W
 arrier\, Autism Research Centre\, University of Cambridge
DTSTART:20210705T143000Z
DTEND:20210705T153000Z
UID:TALK161341@talks.cam.ac.uk
CONTACT:Elizabeth Weir
DESCRIPTION:The breadth of the diagnostic criteria for autism allows for d
 ifferent individuals to access important clinical\, educational\, and soci
 al support services. However\, the substantial heterogeneity in autism is 
 a challenge for investigating the aetiology and translating research findi
 ngs to support autistic people. Using data from up to 12\,893 autistic ind
 ividuals\, we investigate genetic differences between autistic individuals
  based on core and associate autism features\, co-occurring developmental 
 disabilities including intellectual disability\, and sex. We demonstrate t
 hat the core and associate phenotypic profile in autism is genetically com
 plex\, involving both common and rare variants. We identify widespread dif
 ferences in common and rare variants between autistic individuals based on
  sex\, intellectual disability\, and other co-occurring developmental disa
 bilities. Furthermore\, we identify differences in developmental outcomes 
 and sex-bias in genes associated with severe developmental disorders versu
 s other constrained genes. Altogether\, our analyses demonstrate substanti
 al phenotypic and genetic differences in subgroups of autistic individuals
  and highlight avenues to investigate heterogeneity in autism.
LOCATION:https://us02web.zoom.us/j/85130861934?pwd=c1l1czdNSFVaUzdtRDRPSlU
 3Q0VmZz09
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