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SUMMARY:Using stem cell technology to combat age-related neurodegenerative
  diseases - Sally Temple PhD\, Scientific Director\, Neural Stem Cell Inst
 itute\, USA
DTSTART:20210727T150000Z
DTEND:20210727T160000Z
UID:TALK161404@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:We use stem cell technology to create authentic central nervou
 s system cells valuable to combat neurodegenerative diseases. We have disc
 overed a novel stem cell in the adult human retina that we are harnessing 
 for cell replacement therapy in patients with age-related macular degenera
 tion. In addition\, we use cerebral organoids to study how cells change in
  tauopathy. Tauopathies are associated with synapse loss\, neuronal and gl
 ial cell death\, tau aggregation\, and tau hyperphosphorylation\, but whic
 h pathways lead to these neurodegenerative events are not fully resolved. 
 Working with the Tau Consortium\, we have helped establish an extensive co
 llection of iPSC lines and isogenic controls. In a collaborative team\, we
  have examined tau proteaforms\, isoforms\, turnover\, histology\, as well
  as transcriptomic changes\, and  revealed a timecourse of phenotypic alte
 rations associated with tauopathy.
LOCATION:Webinar -  https://zoom.us/j/99447632193?pwd=QU9vbXliNXcvcXZqVFFB
 bHVpd2tSUT09
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