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SUMMARY:Understanding DNA Replication with Nanopore Sequencing\, Deep Lear
 ning\, and Mathematical Modelling - Dr. Michael A. Boemo (Department of Pa
 thology\, University of Cambridge) 
DTSTART:20211013T130000Z
DTEND:20211013T140000Z
UID:TALK161455@talks.cam.ac.uk
CONTACT:Samantha Noel
DESCRIPTION:In the time it takes you to read this sentence\, your body wil
 l produce millions of new cells. It is critical that each of them copied t
 heir genome accurately\; errors in DNA replication are a hallmark of cance
 r and other genetic diseases. My group is developing artificial intelligen
 ce software that measures the movement of DNA replication forks from Oxfor
 d Nanopore sequencing data. Using AI in this way has allowed us to detect 
 sites of DNA replication initiation and fork stalling with a spatial resol
 ution and throughput that exceeds previous microscopy-based methods by sev
 eral orders of magnitude. I will discuss our progress using this technolog
 y in human cancer cells and parasites\, where we are working on how to bet
 ter utilise faulty DNA replication as a therapeutic target. I will also di
 scuss process algebra-based modelling and simulation techniques we are dev
 eloping to help guide our experiments.
LOCATION:CMS\, Meeting Room 15
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