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SUMMARY:Buffering genetic variation in populations - Dr. Ritwick Sawarkar 
 (MRC Toxicology Unit\, University of Cambridge)
DTSTART:20211027T130000Z
DTEND:20211027T140000Z
UID:TALK161458@talks.cam.ac.uk
CONTACT:Samantha Noel
DESCRIPTION:Natural populations harbour enormous genetic variation – dif
 ferences in the coding and non-coding part that give rise to differential 
 susceptibility to infections/ diseases and responsiveness to treatment. Th
 ink of side effects that we get due to covid vaccines – some people have
  strong effects\, some have no effects after vaccination. It is likely tha
 t genetic differences among individuals of the population underlies this v
 ariation in response to vaccines. Cells have evolved multiple mechanisms b
 y which the effects of genetic variation are minimised\, or ‘buffered’
 . Our work focusses on genetic variation in the non-coding parts of the ge
 nome and a cellular strategy dependent on a molecular chaperone. The talk 
 will specifically focus on variation in repetitive parts of the genome and
  single-nucleotide polymorphism\, combining computational tools for data a
 nalysis with hypothesis testing using biochemical approaches.
LOCATION:CMS\,  Meeting Room 15
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