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SUMMARY:Closing The Gap Between Theory and Experiments in The Design of Bi
 omolecular Feedback Circuits - Noah Olsman\, Harvard University
DTSTART:20210805T130000Z
DTEND:20210805T140000Z
UID:TALK161479@talks.cam.ac.uk
CONTACT:Thiago Burghi
DESCRIPTION:Feedback regulation is one of the most fundamental principles 
 in biology\, from the homeostasis that regulates our body temperature down
  to the molecular control mechanisms that ensure that each cell on Earth i
 s producing all of the right proteins and other biological molecules at th
 e right time in order to survive in an uncertain world. Given the many exa
 mples of biological feedback control given to us by evolution\, it is some
 what surprising how difficult it still is for us humans to successfully en
 gineer feedback regulation in synthetic biological circuits. \n\nIn this t
 alk\, I will first discuss theoretical work that I carried out during my P
 hD where we attempted to translate some tools from control theory (using e
 .g.\, Bode's Integral Theorem and some more recent results developed by Fu
 lvio Forni and Rodolphe Sepulchre on dominance analysis) into the domain o
 f biology\, specifically focusing on a novel class of engineered genetic c
 ontrol circuits called an antithetic integral feedback controller. Next\, 
 I will present ongoing work where we are developing novel experimental tec
 hniques that we hope will make it possible to actually use the theory to d
 rive the design and analysis of real synthetic circuits acting in living b
 acterial cells. My goal is to illustrate through this example what I have 
 learned about the gap between the types of tools we use in classical contr
 ol contexts\, and what it is that makes biology such a challenging domain 
 of application for those tools. \n
LOCATION:Online (Zoom)
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