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SUMMARY:The landscape of amyloid misfolding - Prof. Jeremy Schmit (Kansas 
 State University)
DTSTART:20210721T093000Z
DTEND:20210721T103000Z
UID:TALK161485@talks.cam.ac.uk
CONTACT:Akhila Kadgathur Jayaram
DESCRIPTION:Alzheimer's disease is one of many afflictions that are associ
 ated with the formation of beta-sheet rich protein aggregates called amylo
 ids. In this talk I will present a series of analytically tractable toy mo
 dels to probe the fundamental energy barriers and timescales that determin
 e\nthe kinetics of aggregation. We show that the fast dynamics of secondar
 y structure formation can be mapped to exactly solvable random walks in on
 e and two dimensions to understand the dynamics of fibril nucleation and e
 longation. While the random walk steps occur on the nanosecond timescale\,
  the theories show that the time to sample the conformational\nspace is co
 nsistent with the much longer timescales observed in experiments. These ra
 ndom walk models show that the aggregation process occurs by a very differ
 ent mechanism than the funnel model that governs native folding.
LOCATION:https://zoom.us/j/99567836121
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