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SUMMARY:Brain charts for the human lifespan - Richard Bethlehem ( ARC)
DTSTART:20210727T143000Z
DTEND:20210727T153000Z
UID:TALK161524@talks.cam.ac.uk
CONTACT:Elizabeth Weir
DESCRIPTION:Over the past 25 years\, neuroimaging has become a ubiquitous 
 tool in basic research and clinical studies of the human brain. However\, 
 there are no reference standards against which to anchor measures of indiv
 idual differences in brain morphology\, in contrast to growth charts for t
 raits such as height and weight. Here\, we built an interactive online res
 ource (www.brainchart.io) to quantify individual differences in brain stru
 cture from any current or future magnetic resonance imaging (MRI) study\, 
 against models of expected age-related trends. With the goal of basing the
 se on the largest and most inclusive dataset\, we aggregated MRI data span
 ning 115 days post-conception through 100 postnatal years\, totaling 122\,
 123 scans from 100\,071 individuals in over 100 studies across 6 continent
 s. When quantified as centile scores relative to the reference models\, in
 dividual differences show high validity with non-MRI brain growth estimate
 s and high stability across longitudinal assessment. Centile scores helped
  identify previously unreported brain developmental milestones and demonst
 rated increased genetic heritability compared to non-centiled MRI phenotyp
 es. Crucially for the study of brain disorders\, centile scores provide a 
 standardised and interpretable measure of deviation that reveals new patte
 rns of neuroanatomical differences across neurological and psychiatric dis
 orders emerging during development and ageing. In sum\, brain charts for t
 he human lifespan are an essential first step towards robust\, standardise
 d quantification of individual variation and for characterizing deviation 
 from age-related trends. Our global collaborative study provides such an a
 nchorpoint for basic neuroimaging research and will facilitate implementat
 ion of research-based standards in clinical studies.
LOCATION:https://us02web.zoom.us/j/85130861934?pwd=c1l1czdNSFVaUzdtRDRPSlU
 3Q0VmZz09
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