BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:Dissecting the neural circuits underlying prefrontal regulation of reward and threat responsivity in a primate - Professor Angela Roberts\, Physiology\, Development &\; Neuroscience DTSTART:20220215T160000Z DTEND:20220215T170000Z UID:TALK161713@talks.cam.ac.uk CONTACT:Dr Dervila Glynn DESCRIPTION:*Theme: Neurons\, Networks and Circuits*\n\n*Tile: Dissecting the neural circuits underlying prefrontal regulation of reward and threat responsivity in a primate* \n\n*Abstract:* Gaining insight into the over lapping neural circuits that regulate positive and negative emotion is an important step towards understanding the heterogeneity in the aetiology of anxiety and depression and developing new treatment targets. Determining the core contributions of the functionally heterogenous prefrontal cortex to these circuits is especially illuminating given its marked dysregulatio n in affective disorders. This presentation will review a series of studie s in a new world monkey\, the common marmoset\, employing pathway-specific chemogenetics\, neuroimaging\, neuropharmacology and behavioural and card iovascular analysis to dissect out prefrontal involvement in the regulatio n of both positive and negative emotion. Highlights will include the profo und shift of sensitivity away from reward and towards threat induced by lo calised activations within distinct regions of vmPFC\, namely areas 25 and 14 as well as the opposing contributions of this region\, compared to orb itofrontal and dorsolateral prefrontal cortex\, in the overall responsivit y to threat. Ongoing follow-up studies are identifying the distinct downst ream pathways that mediate some of these effects as well as their differen tial sensitivity to rapidly acting anti-depressants. \n\n*Biography: Angel a Roberts* obtained her PhD in neuroendocrinology from University of Cambr idge (1985) and following postdoctoral studies researching into the neural and neurochemical basis of cognitive flexibility was appointed Lecturer i n Department of Anatomy\, Cambridge\, in 1996\, becoming Professor of Beha vioural Neuroscience in 2010. She was elected a Fellow of the Academy of Medical Sciences in 2016. Recent scientific contributions have involved es tablishing non-human primate models of positive and negative emotion regul ation\, fractionating out the distinct prefrontal networks that may underl ie the varied aetiology of affective disorders and elucidating the sensiti vity of these networks to anxiolytics/antidepressants essential for the mo re effective targeting of current pharmacotherapies. She received the Gold man-Rakic Prize for outstanding achievements in Cognitive Neuroscience in 2020\n\n*Register* in advance for this meeting: \nhttps://us02web.zoom.us/ meeting/register/tZwvf-mvrjwrGdcaKPl0cH7zhJvmjX-kF5fc\n\nAfter registering \, you will receive a confirmation email containing information about join ing the meeting. LOCATION:Register on Zoom - link in abstract END:VEVENT END:VCALENDAR