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SUMMARY:Functional redundancy of Drosophila melanogaster SoxB proteins in 
 central nervous system development - Barbara Joo\, Department of Genetics
DTSTART:20211014T120000Z
DTEND:20211014T130000Z
UID:TALK161920@talks.cam.ac.uk
CONTACT:Dr Tamsin Samuels
DESCRIPTION:During neural development\, SoxB proteins are transcriptions f
 actors that play an important role in the maintenance of stem-cell identit
 y. One member of this family\, Sox2 has been successfully used to induce c
 ells into a pluripotent state (iPSCs) and is involved in different disorde
 rs promoting cells self-renewal. Interestingly\, SoxB proteins have shown 
 pioneer and redundant activity even when natural selection imposes evoluti
 onary pressure to prevent gene duplications. Moreover\, a high functional 
 conservation and high levels of sequence similarity\, allow us to assess f
 unctionality in vivo and at a chromatin level using Drosophila melanogaste
 r as our model organism and its genes SoxN and Dichaete\, orthologs of mam
 malian and other vertebrates SoxB genes
LOCATION:Richard King room\, Darwin College
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