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SUMMARY:From Vulnerable Plaque to Vulnerable Brain: Understanding the Role
  of Inflammation in Vascular Health\, Stroke\, and Cerebrovascular Disease
  - Dr Nicholas Evans\, Department of Clinical Neurosciences
DTSTART:20211005T150000Z
DTEND:20211005T160000Z
UID:TALK162028@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:*Theme: Beyond the Neuron: glia\, vascular and immune cells*\n
 \n*Title:* From Vulnerable Plaque to Vulnerable Brain: Understanding the R
 ole of Inflammation in Vascular Health\, Stroke\, and Cerebrovascular Dise
 ase\n\n\n*Abstract:*\nEvery year around 100\,000 people in the UK will hav
 e a stroke. Stroke is a leading cause of adult disability\, and cerebrovas
 cular disease more broadly is a major cause of dementia. Understanding the
 se diseases - both acute and chronic manifestations of cerebrovascular dis
 ease - requires consideration not only of the brain itself\, but also the 
 blood vessels supplying it. Atherosclerosis - the hardening of arteries as
  we age - may predispose to stroke by triggering the formation of blood cl
 ots that block the blood supply to the brain\, but also involves inflammat
 ion that may cause chronic damage to the brain and prime both the brain an
 d body for injury. Understanding this interaction between systemic disease
  and brain health may have important implications for our understanding of
  healthy ageing and provide novel therapeutic approaches for reducing the 
 burden of cerebrovascular disease.\n\n\nThis talk will consider how advanc
 es in imaging may facilitate our understanding of the processes underlying
  atherosclerosis and how it affects the brain in stroke\, as well as work 
 currently underway to translate this understanding into improving treatmen
 ts for stroke.\n\n\n*Biography:* Dr Nicholas Evans is a Clinical Lecturer 
 in Stroke Medicine at the University of Cambridge and a Consultant Stroke 
 Physician at Addenbrooke's Hospital. His primary research focus is on imag
 ing atherosclerosis – the hardening of arteries due to cholesterol – u
 sing positron emission tomography (PET) and magnetic resonance imaging (MR
 I). In particular\, his research considers how inflammation within atheros
 clerosis of the carotid arteries affects atherosclerotic plaque stability 
 to cause a stroke\, as well as how this inflammation affects the brain. Hi
 s work also considers how vascular disease relates to clinical frailty –
  a state of functional decline and loss of physiological reserves – and 
 how this may affect responses to stroke therapies and outcomes. This resea
 rch is a collaboration across the Departments of Medicine (Cardiovascular 
 Medicine)\, Clinical Neurosciences\, Geriatric Medicine\, and Radiology wi
 thin the School of Clinical Medicine.\n\n\nHis clinical training has inclu
 ded rotations within hospitals across the East of England\, and he has und
 ertaken postgraduate training at the University of Dundee and Harvard Univ
 ersity. His PhD was supported by a Research Training Fellowship from The D
 unhill Medical Trust. His work has been awarded the Harvey Prize for Vascu
 lar Medicine (Royal Society of Medicine)\, Binks Young Investigator Award 
 (British Atherosclerosis Society)\, and a Quincentennial Lectureship (Roya
 l College of Physicians)\, as well as awards from the British Geriatrics S
 ociety\, Wellcome Trust\, European Stroke Organisation\, and the British H
 eart Foundation. He is a Junior Research Fellow at Wolfson College.\n\nReg
 ister in advance for this meeting: https://us02web.zoom.us/meeting/registe
 r/tZIld-ispjkqHd0a54jud-hTVgYX8bT1qcvh\n\nAfter registering\, you will rec
 eive a confirmation email containing information about joining the meeting
 .\n\n
LOCATION:Register on Zoom - link in abstract
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