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SUMMARY:Brain and behavioural impacts of early life adversity - Professor 
 Jeff Dalley\, Department of Psychology/Psychiatry
DTSTART:20220426T150000Z
DTEND:20220426T160000Z
UID:TALK162043@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:*Theme: Adaptive Brain Computations*\n\n*Abstract:* Abuse\, ne
 glect\, and other forms of uncontrollable stress during childhood and earl
 y adolescence can lead to adverse outcomes later in life\, including espec
 ially perturbations in the regulation of mood and emotional states\, and s
 pecifically anxiety disorders and depression. However\, stress experiences
  vary from one individual to the next\, meaning that causal relationships 
 and mechanistic accounts are often difficult to establish in humans. This 
 interdisciplinary talk considers the value of research in experimental ani
 mals where stressor experiences can be tightly controlled and detailed inv
 estigations of molecular\, cellular\, and circuit-level mechanisms can be 
 carried out. The talk will focus on the widely used repeated maternal sepa
 ration procedure in rats where rat offspring are repeatedly separated from
  maternal care during early postnatal life. This early life stress has rem
 arkably persistent effects on behaviour with a general recognition that ma
 ternally-deprived animals are susceptible to depressive-like phenotypes. T
 he validity of this conclusion will be critically appraised with convergen
 t insights from a recent longitudinal study in maternally separated rats i
 nvolving translational brain imaging\, transcriptomics\, and behavioural a
 ssessment.  \n\n*Biography:* Jeff Dalley is a Professor in the Departments
  of Psychology and Psychiatry. His research spans the fields of behavioura
 l and cognitive neuroscience\, psychopharmacology and the translation of b
 asic advances in neuroscience to clinical psychopathology\, including schi
 zophrenia\, attention-deficit/hyperactivity disorder\, Parkinson's disease
  and drug addiction.\n\nRegister in advance for this seminar: https://us02
 web.zoom.us/meeting/register/tZYrc-CurzksGtzEOu_NDZoaMd0F99JK4wa_\n\nAfter
  registering\, you will receive a confirmation email containing informatio
 n about joining the meeting.
LOCATION:Register on Zoom - link in abstract
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