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SUMMARY:Mechanisms to medicines in neurodegeneration - Professor Giovanna 
 Mallucci\, Department of Clinical Neurosciences
DTSTART:20211130T160000Z
DTEND:20211130T170000Z
UID:TALK162064@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:*Theme: Lifelong Brain Development*\n\n*Abstract:* Dysregulati
 on of protein synthesis both globally and locally in neurons and astrocyte
 s is a key feature of neurodegenerative diseases.  Aberrant signalling thr
 ough the Unfolded Protein Response (UPR) and related Integrated Stress Res
 ponse (ISR) have become major targets for neuroprotection in these disorde
 rs.  In addition\, other homeostatic mechanisms and stress responses\, inc
 luding the cold shock response\, appear to regulate local translation and 
 RNA splicing to control synapse maintenance and regeneration and can also 
 be targeted therapeutically for neuroprotection.  We have defined the role
  of UPR/ISR and the cold-shock response in neurodegenerative disorders and
  have developed translational strategies targeting them for new treatments
  for dementia.\n\n*Biography:* Giovanna Mallucci is van Geest Professor of
  Clinical Neurosciences and Centre Director of the UK Dementia Research In
 stitute (UK DRI) at the University of Cambridge. Her undergraduate degrees
  were in Physiological Sciences and Medicine from the University of Oxford
 \, with clinical training at University College\, London. She obtained her
  PhD from London University.  Her lab is pioneering interventions targetin
 g common pathways for treatment of dementia.   Her work on the role of the
  unfolded protein response in neurodegenerative disease and its pharmacolo
 gical manipulation was hailed as “turning point in search for medicines 
 to control and prevent Alzheimer’s” http://www.bbc.co.uk/news/health-2
 4462699 and was the 2013/2014 Research for Society MRC success story. She 
 has received numerous national and international awards for her work\, inc
 luding a SciAm50 award for leadership in research as one of the top 50 sci
 entific innovators worldwide and is the recipient of the 2021 Potamkin Pri
 ze for Research in Pick’s Alzheimer’s and Related Disorders\, from the
  American Academy of Neurology and American Brain Foundation.  She has giv
 en many plenary and keynote talks at international conferences and numerou
 s lay talks to the public from patients to benefactors and schoolchildren.
   She is an ERC Consolidator Fellow. In 2017\, she was elected Fellow of t
 he Academy of Medical Sciences. She is Honorary Consultant Neurologist at 
 Addenbrooke's Hospital specialising in Dementia and a Fellow of Churchill 
 College.\n\nRegister in advance for this seminar: https://us02web.zoom.us/
 meeting/register/tZUlcOyrqz4sHNF7X-tDcPRvZLJTs-CBz6AW\n\nAfter registering
 \, you will receive a confirmation email containing information about join
 ing the meeting.
LOCATION:Register on Zoom - link in abstract
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