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SUMMARY:From non-living to living with beads and springs - Andela Šarić\
 , UCL
DTSTART:20211108T163000Z
DTEND:20211108T170000Z
UID:TALK162319@talks.cam.ac.uk
CONTACT:Dr Christoph Schran
DESCRIPTION:The molecular machinery of life is largely created via self-or
 ganisation of individual molecules into functional larger-scaled structure
 s. Such processes are multi-scale in nature and constantly driven far from
  thermodynamic equilibrium. Our group develops minimal coarse-grained comp
 uter models to invstigate how the assembly of a large number of macromolec
 ules results in a living machine\, as well as how such processes can fail\
 , leading to diseases. \n\n \n\nToday I will discuss our strategy for iden
 tifying minimal molecular ingredients that recover the complexity of livin
 g machines in silico. I will discuss the application of such computer mode
 ls on understanding the fundamental mechanism of life -- cell reshaping an
 d cell division. I will show quantitative matching of our minimal models w
 ith live cell data throughout evolution.  Beyond their biological context\
 , these models can help guide the design of artificial structures that are
  able to recapitulate life at the nanoscale.
LOCATION:Dept of Chemistry\, Wolfson Lecture Theatre and Zoom
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