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SUMMARY:Hypothalamic episode generators underlying the neural control of f
 ertility - Professor Allan Herbison\, Physiology\, Development and Neurosc
 ience
DTSTART:20221108T160000Z
DTEND:20221108T170000Z
UID:TALK162460@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:*This talk has been RESCHEDULED until November 8th at 16:00*\n
 \n*Theme: Neurons\, Networks and Circuits*\n\n*Abstract:* The hypothalamus
  controls diverse homeostatic functions including fertility. Neural episod
 e generators are required to drive the intermittent pulsatile and surge pr
 ofiles of reproductive hormone secretion that control gonadal function. St
 udies in genetic mouse models have been fundamental in defining the neural
  circuits forming these central pattern generators and the full range of i
 n vitro and in vivo optogenetic and chemogenetic methodologies have enable
 d investigation into their mechanism of action. The seminar will outline s
 tudies defining the hypothalamic "GnRH pulse generator network" and curren
 t understanding of its operation to drive pulsatile hormone secretion. \n\
 n*Biography:* Allan has spent most of his career studying the hypothalamic
  control of fertility\, and moving backwards and forwards between Cambridg
 e and his home country New Zealand. Upon completing a medical degree at th
 e University of Otago Allan moved to Cambridge to undertake a PhD at The B
 abraham Institute where he continued as a PI until returning to Otago as P
 rofessor of Physiology. With the misfortune of coinciding with the appeara
 nce of the covid pandemic\, Allan recently moved back to Cambridge as Prof
 essor of Neuroendocrinology in PDN supported by the Wellcome Trust.  Resea
 rch at cellular and whole animal levels has relied heavily on genetic mous
 e models to access and manipulate specific neuronal populations responsibl
 e for driving episodic hormone secretion underpinning mammalian fertility.
  Current experiments involve the use of in vivo GCaMP GRIN lens and photom
 etry\, in vitro brain slice recording and in vivo CRISPR-based gene knockd
 own.\n\nRegister in advance for this meeting: https://us02web.zoom.us/meet
 ing/register/tZIocuqgqz4qHNzVOj-fm9aeyHlEDnS8r1g6\n\nAfter registering\, y
 ou will receive a confirmation email containing information about joining 
 the meeting.\n\n
LOCATION:Register on Zoom - link in abstract
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