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SUMMARY:Network science and network medicine: New strategies for understan
 ding and treating the biological basis of mental ill-health - Dr Petra Vé
 rtes\, Department of Psychiatry
DTSTART:20220315T160000Z
DTEND:20220315T170000Z
UID:TALK162463@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:*Theme: Neurons\, Networks and Circuits*\n\nThe last twenty ye
 ars have witnessed extraordinarily rapid progress in basic neuroscience\, 
 including breakthrough technologies such as optogenetics\, and the collect
 ion of unprecedented amounts of neuroimaging\, genetic and other data rele
 vant to neuroscience and mental health. However\, the translation of this 
 progress into improved understanding of brain function and dysfunction has
  been comparatively slow. As a result\, the development of therapeutics fo
 r mental health has stagnated too. One central challenge has been to extra
 ct meaning from these large\, complex\, multivariate datasets\, which requ
 ires a shift towards systems-level mathematical and computational approach
 es. A second challenge has been reconciling different scales of investigat
 ion\, from genes and molecules to cells\, circuits\, tissue\, whole-brain\
 , and ultimately behaviour. In this talk I will describe several strands o
 f work using mathematical\, statistical\, and bioinformatic methods to bri
 dge these gaps. Topics will include: using artificial neural networks to l
 ink the organization of large-scale brain connectivity to cognitive functi
 on\; using multivariate statistical methods to link disease-related change
 s in brain networks to the underlying biological processes\; and using net
 work-based approaches to move from genetic insights towards drug discovey.
  Finally\, I will discuss how simple organisms such as C. elegans can serv
 e to inspire\, test\, and validate new methods and insights in networks ne
 uroscience.\n\nRegister in advance for this meeting: https://us02web.zoom.
 us/meeting/register/tZwsfuGpqjoiEtOhUKplx92IW5t-tiFiYHAv\n\nAfter register
 ing\, you will receive a confirmation email containing information about j
 oining the meeting.\n\n
LOCATION:Register on Zoom - link in abstract
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