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SUMMARY:Disease modification in neurodegenerative disease\, diabetes\, and
  cancer\, via the Hes3 Signalling Axis - Dr Andreas Androutsellis-Theotoki
 s\, CEO/CSO Innate Repair and Assistant Professor\, Technische Universitae
 t
DTSTART:20210930T150000Z
DTEND:20210930T160000Z
UID:TALK162499@talks.cam.ac.uk
CONTACT:Kirsty Shepherd
DESCRIPTION:The Hes3 Signalling Axis is a recently elucidated molecular me
 chanism that regulates the growth and function of multiple types of plasti
 c cell. In the living organism\, under normal conditions\, it is generally
  turned off\, explaining – in part – why it eluded detection until rec
 ently. Its function is revealed when a tissue is subjected to damage\, whi
 ch activates the Axis in specialized cells (including multiple types of st
 em cell)\, thus contributing to regeneration. In vivo work reveals that di
 sruption of the pathway impairs regeneration\, whereas activation promotes
  it\, leading to disease modification in preclinical models of ischemic st
 roke\, Parkinson’s disease\, multiple sclerosis\, and diabetes (types 1 
 and 2). Cancer\, representing a paradigm of out-of-control regeneration\, 
 also utilizes the Axis. Specifically\, at least a subpopulation of cancer 
 cells can activate the pathway: in many biopsies\, at each moment in time\
 , a percentage of cancer cells express the key biomarker\, Hes3. In cultur
 e\, cancer cells can be forced to turn the Axis on or off\, depending on t
 he media formulation\, demonstrating that the same cell can switch between
  the ON and OFF states. This is of relevance to therapy because the drug s
 ensitivities between the two states are very different. In other words\, t
 o kill a cell in the ON position\, you need different treatments than to k
 ill the same cell in the OFF position. So far\, the operation of the Axis 
 has been reported in multiple types of cancer\, including brain\, pancreas
 \, prostate\, breast\, lung\, and rhabdomyosarcoma. Targeting the Axis has
  therapeutic potential: Hes3 RNA interference effectively kills cultured c
 ells\, specifically in the ON position. In fish\, Hes3 promotes cancer pro
 gression. In at least two types of cancer\, high levels of Hes3 expression
  predict a shorter patient survival time. The Hes3 Signalling Axis provide
 s a new molecular logic to develop new treatments for a range of disorders
 .
LOCATION:https://eng-cam.zoom.us/j/83386023727?pwd=VXA5NFZRYzA2K0dnckVUUWx
 1ZnR3dz09
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