BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Cell shape determination: Mechanical competition vs. endogenous ge
 netic programme - Maria Leptin
DTSTART:20211011T133000Z
DTEND:20211011T143000Z
UID:TALK162502@talks.cam.ac.uk
CONTACT:margherita battistara
DESCRIPTION:The intrinsic genetic programme of a cell is not sufficient to
  explain all of the cell’s activities. External mechanical stimuli are i
 ncreasingly recognized as determinants of cell behaviour. In the epithelia
 l folding event that constitutes the beginning of gastrulation in Drosophi
 la\, the genetic programme of the future mesoderm leads to the establishme
 nt of a contractile actomyosin network that triggers apical constriction o
 f cells\, and thereby\, tissue folding. However\, some cells do not constr
 ict but instead stretch\, even though they share the same genetic programm
 e as their constricting neighbours. We show here that tissue-wide interact
 ions force these cells to expand even when an otherwise sufficient amount 
 of apical\, active actomyosin is present. Models based on contractile forc
 es and linear stress-strain responses do not reproduce experimental observ
 ations\, but simulations in which cells behave as ductile materials with n
 on-linear mechanical properties do. Our models show that this behaviour is
  a general emergent property of actomyosin networks in a supracellular con
 text\, in accordance with our experimental observations of actin reorganis
 ation within stretching cells.
LOCATION:Online
END:VEVENT
END:VCALENDAR