BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Collective effects in epithelial cell elimination - Dr. Romain Lev
 ayer (Institut Pasteur)
DTSTART:20210929T160000Z
DTEND:20210929T170000Z
UID:TALK162538@talks.cam.ac.uk
CONTACT:Dr. Adrien Hallou
DESCRIPTION:While the signals regulating apoptosis during development are 
 rather well known\, what sets the precise spatio-temporal distribution of 
 cell death and the adjustment of cell elimination to local perturbations i
 s not well understood. Similarly\, how cells eventually engage in apoptosi
 s and how the removal of cells from epithelial layer is\norchestrated thro
 ugh cell extrusion remained poorly understood\, especially in vivo. In thi
 s seminar\, I will present our recent attempt to dissect these two layers 
 of regulation in the Drosophila pupal notum (a single layer epithelium). I
  will first describe the contribution of EGFR/ERK modulations by mechanics
  in the competitive elimination of cells by oncogenic clones. I will then 
 illustrate how the same pathway help to fine tune the spatio-temporal dist
 ribution of cell elimination during homeostasis through local and transien
 t feedbacks. Eventually I will describe our latest data on the regulation 
 of cell extrusion by a caspase dependent disassembly of microtubules and t
 heir unexpected contribution to epithelial shape stabilization.
LOCATION:Webinar
END:VEVENT
END:VCALENDAR