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SUMMARY:One becomes two: assemblies that split cells across evolution - Dr
  Anđela Šarić\, IST Austria 
DTSTART:20220309T143000Z
DTEND:20220309T153000Z
UID:TALK162592@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:The molecular machinery of life is largely created via self-or
 ganisation of individual molecules into functional larger-scaled assemblie
 s. Such processes are multi-scale in nature and constantly driven far from
  thermodynamic equilibrium. Our group develops minimal coarse-grained mode
 ls to investigate how driven macromolecular assemblies result in living ma
 chines\, and how such processes can fail\, leading to diseases. \n\nToday 
 I will present our research on computational modelling of active elastic p
 rotein filaments that dynamically change their conformations to reshape an
 d cut cells. I will present the comparison of our simulation results to li
 ve cell data on reshaping processes across evolution — from cellular tra
 fficking to cell division. I will finish with our recent efforts in comput
 ationally evolving assemblies that perform a desired function. Beyond thei
 r biological context\, our models can help guide the design of artificial 
 structures that are able to mimic life at the nanoscale.
LOCATION:Zoom and Dept of Chemistry\, Wolfson Lecture Theatre
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