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SUMMARY:The liquid genome: Multiscale modelling of DNA packaging inside ce
 lls  - Dr Rosana Collepardo-Guevara\, University of Cambridge
DTSTART:20220317T111500Z
DTEND:20220317T121500Z
UID:TALK162595@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:The three-dimensional organisation of the DNA is one of the gr
 eat marvels of physical biology. By winding around a special class of prot
 eins\, the metre-long DNA manages to compress enormously to fit inside tin
 y (6 μm) nuclei\, avoid entanglement and\, moreover\, maintain exquisite 
 control over the accessibility of the information it carries. The structur
 e of this remarkable complex of DNA and proteins\, known as chromatin\, de
 termines how easily the DNA can be accessed and\, thus\, it is intimately 
 linked to gene expression regulation. In this talk\, I will present our mu
 ltiscale modelling techniques designed to investigate the structure of chr
 omatin in conditions that mimic those inside cells (Farr et al\, Nature Co
 mmunications\, 2021). I will discuss why nucleosomes\, the building blocks
  of chromatin\, should be viewed as highly plastic particles that foster m
 ultivalent interactions and promote chromatin’s liquid-like properties. 
  
LOCATION:Zoom and Dept of Chemistry\, Wolfson Lecture Theatre
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