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SUMMARY:Multiscale network neuroscience: linking cells\, networks and symp
 toms in brain disease - Dr Linda Douw
DTSTART:20211104T150000Z
DTEND:20211104T160000Z
UID:TALK162817@talks.cam.ac.uk
CONTACT:Sarah Morgan
DESCRIPTION:Most brain diseases and disorders are characterized by alterat
 ions in functioning at multiple scales and in various modalities\, which h
 ave mostly been studied separately up to now. In for example glioma\, the 
 most commonly occurring type of primary brain tumor\, cellular hyperexcita
 bility around the tumor is induced by excess glutamate secretion\, which i
 mpacts local circuitry. At the large-scale network level\, patients often 
 display increased local connectivity and loss of integrative connectivity\
 , in part depending on the modality used to construct networks. Finally\, 
 patients' symptoms range from cognitive deficits and seizures to fatigue a
 nd depression\, which are all interrelated. In this talk\, I will discuss 
 our recent multiscale and multimodal studies in different brain diseases (
 e.g. glioma\, multiple sclerosis\, temporal lobe epilepsy\, Alzheimer's di
 sease) and healthy controls. Multiscale approaches may ultimately allow fo
 r better understanding of the multidimensional nature of brain disease and
  may inform more targeted treatments thereof.
LOCATION:Online
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