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SUMMARY:Hierarchical Neurodevelopment: Patterns\, Plasticity\, and Implica
 tions for Mood Psychopathology - Valerie Sydnor
DTSTART:20211202T150000Z
DTEND:20211202T160000Z
UID:TALK162823@talks.cam.ac.uk
CONTACT:Sarah Morgan
DESCRIPTION:The human brain undergoes a uniquely prolonged period of corti
 cal development. During childhood and adolescence\, cortical development p
 rogresses from primary and unimodal cortices with sensory and motor functi
 ons to transmodal association cortices subserving executive\, socioemotion
 al\, and mentalizing functions. The spatiotemporal patterning of cortical 
 maturation thus proceeds in a hierarchical manner\, conforming to an evolu
 tionarily rooted\, sensorimotor-to-association axis of cortical organizati
 on. This developmental program serves to enhance feature variation between
  lower-order and higher-order regions\, endowing the brain’s association
  cortices with unique properties. However\, protracted plasticity within l
 ate-maturing association cortices\, which represents a defining feature of
  the human developmental program\, also confers risk for mood-related psyc
 hopathology. In this talk\, I will present a spatial and temporal model of
  human neurodevelopment that captures the protracted and heterochronous na
 ture of cortical maturation\, and that provides insight into how our speci
 es’ maturational course enhances both our cognitive repertoire and our v
 ulnerability to affective illness. I will begin by describing hierarchical
  cortical topography and the sensorimotor-association axis. A review of ne
 uroimaging evidence of hierarchical neurodevelopment will follow\, with an
  emphasis on work that has characterized the temporal unfolding of critica
 l period plasticity mechanisms. I will conclude by discussing how developm
 ent can inform our understanding of youth mood psychopathology and windows
  for intervention.
LOCATION:Online
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