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SUMMARY:Investigating the fundamental circuit pathology in schizophrenia u
 sing computational modelling of brain imaging data - Dr Rick Adams
DTSTART:20211021T120000Z
DTEND:20211021T130000Z
UID:TALK163234@talks.cam.ac.uk
CONTACT:Sarah Morgan
DESCRIPTION:It has long been hypothesized that there is a disruption of th
 e normal balance between excitatory and inhibitory transmission in cortica
 l circuits in schizophrenia. The exact nature of this disruption is unclea
 r\, however: is there insufficient excitation? Or insufficient inhibition?
  Or some combination of both? Furthermore\, several M/EEG paradigms show w
 ell-replicated abnormalities in schizophrenia\, e.g. mismatch negativity\,
  auditory steady-state response to 40 Hz stimulation\, and resting EEG spe
 ctra. Can these abnormalities all be attributed to a common excitatory or 
 inhibitory pathology? I attempt to answer these questions using a neuroima
 ging dataset comprising controls (n=107)\, subjects diagnosed with schizop
 hrenia (n=108) and their relatives (n=57). Each participant underwent rest
 ing EEG\, mismatch negativity\, auditory steady-state response at 40 Hz\, 
 and resting state fMRI\, and I used dynamic causal modelling across paradi
 gms to infer changes in synaptic gain on excitatory and inhibitory neurons
  in schizophrenia\, and the relationship of these changes to symptoms of t
 he disorder. I will discuss what the findings might mean for the fundament
 al disease process underlying schizophrenia\, glutamatergic treatments\, a
 nd the possibility of model-based biomarkers of synaptic gain.
LOCATION:Online
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