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SUMMARY:Hippocampal LTP and Psychiatry: The Prime Suspect - David Bannerma
 n (University of Oxford)
DTSTART:20211015T151500Z
DTEND:20211015T170000Z
UID:TALK163390@talks.cam.ac.uk
CONTACT:Psychology Reception
DESCRIPTION:It is nearly 50 years since Bliss and Lomo first reported the 
 long-lasting potentiation of synaptic transmission in the hippocampus (now
  long-term potentiation\; LTP). Subsequently\, deficits in hippocampal syn
 aptic plasticity has been implicated in various psychiatric disorders incl
 uding schizophrenia\, depression and Alzheimer’s Disease. Hippocampal LT
 P has become one of the most widely studied phenomena in neuroscience\, an
 d enormous resources have been poured into research efforts to develop tre
 atment strategies for these disorders that target hippocampal LTP but with
  limited success. This failure\, at least in part\, reflects a lack of und
 erstanding as to the precise psychological sequelae of hippocampal LTP. Th
 e idea that hippocampal LTP provides the neural substrate for the formatio
 n of associative memories has predominated in neuroscience text books\, al
 though the empirical support for this hypothesis is limited at best. Here 
 we provide an alternative account of the role of hippocampal synaptic plas
 ticity in the priming of memories. This account can explain why deficits i
 n hippocampal synaptic plasticity can lead to deficits in episodic memory 
 retrieval in some cases\, but psychosis in disorders like schizophrenia in
  others. It can also potentially account for the learning processes that m
 ight underpin the improvement in mood following anti-depressant treatment 
 in patients.
LOCATION:Zoom meeting
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