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SUMMARY:ApoE\, Ab and Alzheimer’s disease: From test tube to transgenic 
 mice - Mary Jo LaDu\, University of Illinois at Chicago
DTSTART:20211013T150000Z
DTEND:20211013T160000Z
UID:TALK163861@talks.cam.ac.uk
CONTACT:Alyssa Miller
DESCRIPTION:Seminar Outline (Major concepts to be discussed):\n\nBackgroun
 d:\n* Alzheimer’s disease (AD) is the most common cause of dementia.  Wh
 ile rare\, familial AD is caused by genetic mutations that increase the pr
 oduction of Ab42.\n* Age\, APOE genotype and sex are the universal biologi
 cal variables (UBV) of AD risk.\n\nSDS-stable apoE/Ab complexes are apoE i
 soform specific (apoE3/Ab > apoE4/Ab).        \n* Biochemical detection\n*
  In vitro function\n\nAb42 oligomers and fibrils\n* Biochemical assembly\n
 * In vitro function\n\nThe development of reagents for in vivo studies:\n*
  Optimization of a 3-step sequential protein extraction\n* Characterizatio
 n of a new Ab-specific monoclonal antibody\n* Development of oligomer-spec
 ific ELISA\n* Generation of the EFAD transgenic mouse model\n\nThe EFAD tr
 ansgenic mice develop AD-relevant pathology that increases significantly w
 ith age\, APOE4 and female sex\, mirroring human AD risk.\n
LOCATION:https://zoom.us/j/92564124601
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