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SUMMARY:Tea Club Seminar - Ritwick Sarwarkar - &quot\;Host chromatin respo
 nse to SARS-CoV-2 et al&quot\; - Ritwick Sarwarkar
DTSTART:20211026T113000Z
DTEND:20211026T130000Z
UID:TALK164503@talks.cam.ac.uk
CONTACT:Ben Luisi
DESCRIPTION:A variety of environmental stressors\, infections and neurodeg
 enerative conditions cause global transcriptional downregulation inhuman c
 ells\, a phenomenon we termed as Stress-Induced Transcriptional Attenuatio
 n (SITA). In the talk\, I will discuss our work on understanding the mecha
 nism underlying SITA that has led us to uncover novel nuclear condensates 
 formed by liquid-liquid phase separation. Similar transcriptional downregu
 lation is also seen in lung cells upon SARS-CoV-2 infection\, identifying 
 therapeutic avenues.
LOCATION:Biochemistry Zoom
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