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SUMMARY:Defining genetic and environmental determinants of malaria transmi
 ssion - Prof Matthew Marti. University of Glasgow.
DTSTART:20221130T160000Z
DTEND:20221130T170000Z
UID:TALK164530@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Malaria parasites have coevolved with humans over thousands of
  years\, mirroring their migration out of Africa. They persist to this day
 \, despite continuous elimination efforts worldwide. Life-history theory p
 redicts that parasites can adjust investment into (within-host) replicatio
 n versus (between-host) transmission\, dependent on the environmental cond
 itions. Studies in P. falciparum revealed that epigenetic mechanisms regul
 ate the plasticity in sexual conversion rates (i.e. the proportion in a gi
 ven asexual cohort that produce sexual\, transmissive progeny) in response
  to changes in the within-host environment. Given the spread and persisten
 ce of malaria parasites across a wide range of transmission settings\, it 
 is likely that the sexual conversion rate is also be subject to natural se
 lection. I will present data demonstrating that both environmental and gen
 etic factors contribute to the regulation of malaria transmission.\n\nThis
  talk will be broadcasted via Zoom. Please use this "link":https://zoom.us
 /j/95026514738?pwd=aUtoam1zbDRYYWU0M1Nob2VPQXNvZz09 to gain access. 
LOCATION:Seminar Room\, Tennis Court Road\, Dept of Pathology.
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