BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Understanding microglial dynamics from development to age-related 
 neurological diseases - Diego Gomez-Nicola\, University of Southampton\, U
 .K.
DTSTART:20211101T160000Z
DTEND:20211101T170000Z
UID:TALK164551@talks.cam.ac.uk
CONTACT:47293
DESCRIPTION:Microglial cells are the main resident immune cells of the bra
 in and play crucial roles in the regulation of normal and pathological neu
 ral functions. Our lab aims at studying the balance of the numbers of micr
 oglia from development to ageing\, to better understand the roles of these
  cells in brain function and dysfunction\, through a multidisciplinary app
 roach using in vivo models\, genetic molecular tools and behavioural analy
 sis. We aim to define how microglial cells control their numbers and pheno
 type during not only healthy ageing\, but also disease.\nHere we will disc
 uss the rationale for studying and targeting neuroinflammation in Dementia
 \, and illustrate identification and validation of key therapeutic targets
 . We will discuss data derived from a multidisciplinary approach combining
  the study of laboratory models of chronic neurodegeneration\, including p
 rion disease\, Alzheimer’s disease (AD) and ALS\, with the study of post
 -mortem samples from patients. This will be connected with the study of mi
 croglial dynamics across the healthy life course\, highlighting key specie
 s-specific differences as well as identifying the long term consequences o
 f the dysregulation of the dynamics of this population.
LOCATION:https://zoom.us/j/92796686042?pwd=bStrTUNHajBaNGJnVjV1cit5ZCtNdz0
 9
END:VEVENT
END:VCALENDAR