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SUMMARY:The generation of cortical novelty responses through inhibitory pl
 asticity - Nicholas Gale\, DAMTP\, University of Cambridge
DTSTART:20211103T170000Z
DTEND:20211103T180000Z
UID:TALK165259@talks.cam.ac.uk
CONTACT:Katharina Zuhlsdorff
DESCRIPTION:Animals depend on fast and reliable detection of novel stimuli
  in their environment. Neurons in multiple sensory areas respond more stro
 ngly to novel in comparison to familiar stimuli. Yet\, it remains unclear 
 which circuit\, cellular\, and synaptic mechanisms underlie those response
 s. Here\, we show that spike-timing-dependent plasticity of inhibitory-to-
 excitatory synapses generates novelty responses in a recurrent spiking net
 work model. Inhibitory plasticity increases the inhibition onto excitatory
  neurons tuned to familiar stimuli\, while inhibition for novel stimuli re
 mains low\, leading to a network novelty response. The generation of novel
 ty responses does not depend on the periodicity but rather on the distribu
 tion of presented stimuli. By including tuning of inhibitory neurons\, the
  network further captures stimulus-specific adaptation. Finally\, we sugge
 st that disinhibition can control the amplification of novelty responses. 
 Therefore\, inhibitory plasticity provides a flexible\, biologically plaus
 ible mechanism to detect the novelty of bottom-up stimuli\, enabling us to
  make experimentally testable predictions.
LOCATION:Zoom
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